Cytidine And dCMP Deaminase Domain Containing Protein 1 (CDADC1)

CDADC1 belongs to the cytidine and deoxycytidylate deaminase family. Widely expressed. Expressed at high levels in the testis. May play an important role in testicular development and spermatogenesis.

Cytidine deaminase, an enzyme found in the supernatant fluid of hepatocytes, granulocytes and tumor cells, and in plasma, degrades the antitumor agents cytosine arabinoside and 5-azacytidine. Uridine and its analogs, 3-deazauridine, 5-bromodeoxyuridine, 5-fluorodeoxyuridine and 6-azauridine, were found to competitively inhibit cytidine deaminase; the most potent inhibitor was 3-deazauridine. In addition, deoxycytidylate deaminase, which degrades cytosine arabinoside monophosphate to the inactive uracil arabinoside monophosphate, was competitively inhibited by 3-deazauridine monophosphate, as well as by the nucleotides of other uridine analogs.