Cytidine Monophosphate Kinase 2 (CMPK2)

Mitochondrial UMP-CMP kinase is a component of the salvage pathway for nucleotide synthesis. Other enzymes of the salvage pathway include thymidine kinase-2 (TK2), deoxynucleotidase-2 (NT5M), deoxyguanosine kinase (DGUOK), adenylate kinase-2 (AK2), adenylate kinase-3 (AK3), adenylate kinase-3-like-1 (AK3L1), and nucleoside diphosphate kinase (NME4).

The deduced 449-amino acid human CMPK2 protein contains a thymidylate kinase domain and is predicted to have an ATP/GTP-binding motif, a LID domain, an adenine-base-binding loop, a catalytic site, and a possible substrate-binding site. The first 22 amino acids are a mitochondrial targeting signal. A GFP-tagged recombinant molecule localized CMPK2 to mitochondria.