Cytochrome P450 4F12 (CYP4F12)

CYP4F12 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid; however, its physiological function has not been determined. This gene is part of a cluster of cytochrome P450 genes on chromosome 19.

CYP4F12 catalyzed the oxidation of the omega-side chains of 2 stable prostaglandin (PG) H2 analogs, 11,9-epoxymethano-PGH(2) and 9,11-diazo-15 deoxy-PGH(2). It oxidized the omega-side chain of leukotriene B4 (LTB4) poorly.