Cytochrome b-245 Alpha Polypeptide (CYBa)

Cytochrome b is composed of a light chain (alpha) and a heavy chain (beta). Cytochrome b-245 light chain is the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells.The CYBA gene encodes the alpha subunit, also known as the light chain, of cytochrome b(-245), which is a component of the NADPH oxidase (NOX) complex responsible for the respiratory burst in phagocytes.The CYBB gene is an X-linked gene which encodes the cytochrome b beta subunit, also known as the heavy chain.