Cytochrome b-561 Domain Containing Protein 1 (CYB561D1)

Cytochrome b561 is a major transmembrane protein that is specific to catecholamine and neuropeptide secretory vesicles of the adrenal medulla, pituitary gland, and other neuroendocrine tissues. This 30-kD cytochrome is present in both the small synaptic vesicles and the large dense core vesicles (chromaffin granules) of the tissues.

Knockdown of a cytochrome B-like gene (CYB561D1) and a CDC2-related kinase, CRKRS (CRK7), the exact functions of which are unknown, blocked mitosis in both U20S and HeLa and did not DAVID-map to cell cycle. CYB561D1 was detected at higher levels on the 8-Cell and hES cell arrays than either the fibroblast or iPS cell arrays, whereas CRKRS was detected at higher levels on the 8-Cell arrays than all other cell types .