Cytohesin Interacting Protein (CYTIP)

Cytohesin-interacting protein contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, and it does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells.

Natural killer (NK) cells are lymphocytes that are able to destroy a wide range of target cells without prior sensitization. Dixon et al. (1993) isolated a cDNA encoding PSCDBP from a human cDNA subtraction library constructed by subtracting T helper Jurkat cell messages from NK cell messages. They stated that this PSCDBP cDNA may lack 5-prime coding sequence. The predicted protein contains 2 possible leucine zipper domains, a putative C-terminal nuclear targeting signal, and 4 consecutive glu residues near the C terminus; it does not have any hydrophobic regions.