D-Tyrosyl tRNA Deacylase 1 (DTD1)

By screening a human fetal brain cDNA library, Meng et al. (2002) identified DTD1. The deduced 209-amino acid protein has a predicted molecular mass of 23.4 kD and contains potential sites for phosphorylation and O-glycosylation. DTD1 shares 94% identity with its mouse ortholog. Northern blot analysis detected a 1.5-kb transcript in human fetal brain. PCR analysis of human tissues detected high expression in adult brain, testis, ovary, spleen, and fetal brain, and moderate expression in adult colon, thymus, and small intestine and fetal liver, lung, thymus, spleen, heart, and kidney.

Meng et al. (2002) determined that the DTD1 gene contains 6 exons.By genomic sequence analysis, Meng et al. (2002) mapped the DTD1 gene to chromosome 20p11.