D4, Zinc And Double PHD Fingers Family 3 (DPF3)

Cer-d4, a conserved gene homologous to Neuro-d4 (DPF1). The human protein is the apparent homolog of the mouse Cer-d4 protein.DPF3 gene contains 12 exons and spans over 275 kb. The deduced 378-amino acid DPF3B protein contains an N-terminal 2/3 domain, which includes a putative nuclear localization signal, followed by a nuclear receptor interaction domain, a C2H2 Kruppel-like zinc finger, and 2 C-terminal plant homeodomains (PHDs). The deduced truncated isoform, DPF3A, contains 357 amino acids and is identical to DPF3B through the first 290 amino acids, but it contains only a single truncated PHD finger at its C terminus.The deduced protein contains 356 amino acids. Northern blot analysis detected multiple Cerd4 transcripts in mouse retina, cerebellum, and testis only.