DDB1 And CUL4 Associated Factor 11 (DCAF11)

The deduced 546- and 520-amino acid WDR23 isoforms differ only in the presence or absence of a 26-amino acid insert near the N terminus. Both isoforms contain 7 WD40 repeats and a conserved DW box motif that overlaps WD40 repeat 5.

The transcription factor Skn1 (POU2F3) protects C. elegans from stress and promotes longevity. Loss of Wdr23 function caused accumulation of Skn1 in intestinal nuclei, elevation of Skn1 protein levels, constitutive transcription of detoxification genes, and increased longevity and stress resistance. Wdr23 interacted with the Ddb1-Cul4 complex and presumably targeted Skn1 for proteasomal degradation.Wdr23 is a negative regulator of Skn1 in C. elegans.