DDB1 And CUL4 Associated Factor 15 (DCAF15)

DCAF15 Interacts with DDB1 and CUL4A.May be involved in ubiquitination and degradation through a DBB1-CUL4 E3 protein-ubiquitin ligase. This gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small (DDB2) subunit. This protein functions in nucleotide excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform macular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients.