DDB1 And CUL4 Associated Factor 7 (DCAF7)

The An1, An2, and An11 loci control the pigmentation of petunias by stimulating transcription of anthocyanin genes. By Southern blot analysis with a petunia An11 probe, followed by EST database searching and PCR, de Vetten et al. (1997) obtained a cDNA encoding human AN11.

The deduced 342-amino acid, WD repeat-containing protein is 53% identical to the petunia An11 protein and is conserved in worms and yeast, which do not produce anthocyanins. Functional analysis showed that human AN11 could partially complement a petunia An11 mutant. De Vetten et al. (1997) concluded that An11 is involved in signal transduction in petunias.