DEAD Box Polypeptide 28 (DDX28)

DDX28 is an RNA helicase, which unwind double-stranded RNA using nucleoside triphosphates as an energy source. RNA helicases participate in essentially all cellular processes that involve RNA.

The deduced 540-amino acid protein has a calculated molecular mass of 59 kD. DDX28 contains an N-terminal mitochondrial targeting signal, a putative leucine-rich nuclear export signal, a nuclear localization signal, and all of the well conserved DEAD box helicase motifs. It also has several potential serine and threonine phosphorylation sites, but no tyrosine phosphorylation sites. DDX28 shares only limited similarity with other RNA helicases in a region of 300 to 400 amino acids containing all the conserved DEAD box motifs.