Defective In Sister Chromatid Cohesion 1 (DSCC1)

CHTF18, CHTF8, and DSCC1 are components of an alternative replication factor C (RFC) complex that loads PCNA onto DNA during S phase of the cell cycle.DSCC1 protein contains 393 amino acids and has a calculated molecular mass of 45 kD.

The deduced protein has a calculated molecular mass of 44.8 kD and has 2 regions that share a high degree of conservation with yeast Dscc1. Immunohistochemical analysis showed that CHTF18, CHTF8, and DSCC1 localized to nuclear heterochromatin in a diffuse manner and appeared less abundant in nucleoli. SDS/PAGE analysis detected DSCC1 with an apparent molecular mass of about 45 kD.