Dehydrogenase/Reductase SDR Family, Member 1 (DHRS1)

By large scale DNA sequencing, Wu et al. (2002) cloned a novel cDNA, designated DHRS1, from a human fetal cDNA library. The deduced 313-amino acid DHRS1 protein has a molecular mass of 33.9 kD and contains a short-chain dehydrogenase/reductase (SDR) domain.

Northern blot analysis detected DHRS1 transcripts of 0.9 and 1.4 kb in several human tissues; the former was most abundant in heart, and the latter most abundant in liver. Wu et al. (2002) determined that the DHRS1 gene contains 9 exons and spans 9.2 kb.

By sequence analysis, Wu et al. (2002) mapped the DHRS1 gene to chromosome 14q21.3.