Dehydrogenase/Reductase SDR Family, Member 7B (DHRS7B)

DHRS7B belongs to the short-chain dehydrogenases/reductases (SDR) family. This gene is located within the Smith-Magenis syndrome region on chromosome 17.

The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases. As the first member of this family to be characterised was Drosophila alcohol dehydrogenase, this family used to be called 'insect-type', or 'short-chain' alcohol dehydrogenases. Most member of this family are proteins of about 250 to 300 amino acid residues. Most dehydrogenases possess at least 2 domains, the first binding the coenzyme, often NAD, and the second binding the substrate.