Deiodinase, Iodothyronine, Type III (DIO3)
ITDI3; TXDI3; Type-III 5'-deiodinase
DIO3 belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
Organism species: Homo sapiens (Human)
- Customized Service n/a Recombinant Deiodinase, Iodothyronine, Type III (DIO3) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Deiodinase, Iodothyronine, Type III (DIO3) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Deiodinase, Iodothyronine, Type III (DIO3) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Deiodinase, Iodothyronine, Type III (DIO3) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Deiodinase, Iodothyronine, Type III (DIO3) ELISA Kit Customized Service Offer
Organism species: Mus musculus (Mouse)
- Recombinant protein RPF989Mu01 Recombinant Deiodinase, Iodothyronine, Type III (DIO3) In Stock
- Recombinant protein RPF989Mu02 Recombinant Deiodinase, Iodothyronine, Type III (DIO3) In Stock
- Polyclonal antibody PAF989Mu01 Polyclonal Antibody to Deiodinase, Iodothyronine, Type III (DIO3) In Stock
- Polyclonal antibody PAF989Mu02 Polyclonal Antibody to Deiodinase, Iodothyronine, Type III (DIO3) In Stock
- Sandwich ELISA SEF989Mu ELISA Kit for Deiodinase, Iodothyronine, Type III (DIO3) In Stock
Organism species: Rattus norvegicus (Rat)
- Recombinant protein RPF989Ra01 Recombinant Deiodinase, Iodothyronine, Type III (DIO3) In Stock
- Polyclonal antibody PAF989Ra01 Polyclonal Antibody to Deiodinase, Iodothyronine, Type III (DIO3) In Stock
- Monoclonal antibody MAF989Ra21 Monoclonal Antibody to Deiodinase, Iodothyronine, Type III (DIO3) In Stock
- Sandwich ELISA SEF989Ra ELISA Kit for Deiodinase, Iodothyronine, Type III (DIO3) In Stock