Derlin 1 (DERL1)

Derlin-1 is a widely expressed protein, with strong signals obtained by immunoblotting from liver, spleen, pancreas, lung, thymus, and ovary. Despite the presence of Derlin-1 sequences in brain cDNA libraries, immunoreactivity was not detected in brain.Derlin-1 as an ER membrane protein essential for US11-mediated dislocation of the major histocompatibility complex (MHC) class I heavy chain from the ER to the cytosol, and showed that Derlin-1 mediates the degradation of 2 different type 1 membrane proteins, class I MHC heavy chain and US2.The central component of the complex, Derlin-1, was found to associate with different substrates as they move through the membrane. Inactivation of Derlin-1 in C. elegans caused ER stress.