Dihydrolipoyl Transacetylase (DLAT)

DLTA; PDC-E2; PBC; M2 antigen complex 70 kDa subunit; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Pyruvate dehydrogenase complex E2
Dihydrolipoyl Transacetylase (DLAT)
Dihydrolipoyl transacetylase is the component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
Organism species: Rattus norvegicus (Rat)
  • Protein RPA696Ra01Recombinant Dihydrolipoyl Transacetylase (DLAT)Customize
  • AntibodyPAA696Ra01Polyclonal Antibody to Dihydrolipoyl Transacetylase (DLAT)Customize
  • AntibodyMAA696Ra21Monoclonal Antibody to Dihydrolipoyl Transacetylase (DLAT)Customize
  • Assay KitSEA696RaELISA Kit for Dihydrolipoyl Transacetylase (DLAT)Customize
  • Assay KitSCA696RaCLIA Kit for Dihydrolipoyl Transacetylase (DLAT)Customize
Organism species: Danio rerio (Zebrafish)
  • Protein RPA696Fi01Recombinant Dihydrolipoyl Transacetylase (DLAT)Customize
  • AntibodyPAA696Fi01Polyclonal Antibody to Dihydrolipoyl Transacetylase (DLAT)Customize
  • AntibodyMAA696Fi21Monoclonal Antibody to Dihydrolipoyl Transacetylase (DLAT)Customize
  • Assay KitSEA696FiELISA Kit for Dihydrolipoyl Transacetylase (DLAT)Customize
  • Assay KitSCA696FiCLIA Kit for Dihydrolipoyl Transacetylase (DLAT)Customize
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