Dihydrouridine Synthase 4 Like Protein (DUS4L)

Dihydrouridine Synthase 4 Like Protein (DUS4L), Belongs to the dus family. Dus4 subfamily. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

Dihydrouridine is a highly abundant modified nucleoside found widely in tRNAs of eubacteria, eukaryotes, and some archaea. In cytoplasmic tRNA of Saccharomyces cerevisiae, dihydrouridine occurs exclusively at positions 16, 17, 20, 20A, 20B, and 47. The known dihydrouridine synthases Dus1p and Dus2p and two previously uncharacterized homologs, Dus3p (encoded by YLR401c) and Dus4p (YLR405w), are required for all of the dihydrouridine modification of cytoplasmic tRNAs in S. cerevisiae.