Dipeptidyl Peptidase 3 (DPP3)

Dipeptidyl-peptidase 3 is a protein that is a member of the S9B family in clan SC of the serine proteases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins.

Increased activity of this protein is associated with endometrial and ovarian cancers. Alternate transcriptional splice variants have been characterized. DPP3 shows zinc-dependent metalloprotease activity and contains a conserved HELLGH motif with similarity to the zincin HExxH consensus motif. the molecular mass of full-length DPP3 is 82.5 kD; by SDS-PAGE, the apparent molecular mass is 81.2 kD.