Disco Interacting Protein 2 Homolog B (DIP2B)

The transcript contains a repetitive element in its 3-prime UTR. RT-PCR ELISA detected moderate expression in adult brain and in all specific adult brain regions examined. Expression was weaker in adult liver, kidney, spleen, and ovary, and in fetal brain and liver, with little to no expression in all other tissues examined.

Winnepenninckx et al. (2007) identified DIP2B as the gene associated with fragile site FRA12A on chromosome 12. The predicted 1,576-amino acid DIP2B protein contains a DMAP1 (DNMAP1)-binding domain and 2 AMP-binding domains. Northern blot analysis detected a 9-kb transcript in most tissues examined. Within specific brain regions, highest expression was in cerebral cortex and frontal and parietal lobes.