DnaJ/HSP40 Homolog Subfamily B, Member 4 (DNAJB4)

DNAJB4 belongs to the evolutionarily conserved DNAJ/HSP40 protein family. For background information on the DNAJ family.the expression of DNAJB4 increased following heat-shock treatment in human liver and pancreas carcinoma cell lines.

Using the G protein beta subunit (GNB1) as bait in a yeast 2-hybrid screen of a liver cDNA library, Hoe et al. (1998) cloned DNAJB4, which they called HLJ1. The deduced 337-amino acid protein contains an N-terminal J domain and a glycine and phenylalanine (G/F)-rich region. It shares 84% sequence similarity with DNAJB1 . Northern blot analysis detected high expression in skeletal muscle, heart, and pancreas, and lower expression in brain, placenta, and liver.