Dopamine is an endogenous catecholamine that influences many cellular activities, including behavior, hormone synthesis and release, blood pressure and intracellular ion transport.
gene encodes the D1
subtype of the dopamine receptor. The D1
subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1
receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2
-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene.