Double Homeobox Protein A (DUXA)

Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the DUXA homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple, related processed pseudogenes have been found which are thought to reflect expression of this gene in the germ line or embryonic cells.

The deduced 204-amino acid protein contains 2 homeodomains separated by a 26-amino acid spacer. EST analysis detected DUXA expressed in a chondrosarcoma cell line.DUXA gene contains 6 exons and spans about 15.8 kb.