Doublecortin Domain Containing Protein 2B (DCDC2B)

DCDC2B encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization.

Serine/threonine protein kinase domains were found in three human/mouse proteins (DCLK, DCLK2, and DCLK3), and a ricin domain predicted to bind carbohydrates was found in a human/mouse protein referred to as FLJ46154. The structure of the human FLJ46154 and DCDC2B proteins differed from other proteins with tandem repeats; they contained a repeat more similar to DCX C-terminal repeat, which appeared in the N-terminal part of this protein, and a second repeat more similar to DCX N-terminal repeat. In the mouse orthologs of these two proteins, only one DCX domain was present.