Dual Specificity Tyrosine Phosphorylation Regulated Kinase 4 (DYRK4)

Dual-specificity kinases, such as DYRK4, play key roles in cell proliferation, survival, and development (Zhang et al., 2005). Becker et al. (1998) cloned mouse Dyrk4. Northern blot analysis of several rat tissues detected Dyrk4 expression only in testis. Zhang et al. (2005) stated that the DYRK4 protein contains a DYRK homology box in its N-terminal half, followed by a central kinase domain with a YxY loop.

Zhang et al. (2005) determined that the DYRK4 gene contains 12 exons and spans more than 23 kb. Zhang et al. (2005) stated that the DYRK4 gene maps to chromosome 12pter-p13.31. In biochemistry, a dual-specificity kinase (EC 2.7.12.1) is a kinase that can act as both tyrosine kinase and serine/threonine kinase.