Dynamin Binding Protein (DNMBP)

DNMBP belongs to the DBL family of guanine nucleotide exchange factors and plays a role in the regulation of cell junctions. The transcript contains a repetitive element in its 3-prime UTR, and the deduced protein contains motifs suggesting it is a guanine nucleotide regulatory protein. RT-PCR ELISA detected moderate expression in ovary, testis, liver, and lung and low expression in all other tissues examined. Expression was low in all specific brain regions examined and moderate in spinal cord.The deduced 1,577-amino acid protein has a calculated molecular mass of 178 kD. It has 4 N-terminal SH3 domains, followed by a proline-rich region, a coiled-coil domain, a DBL homology (DH) domain, a BIN / amphiphysin /Rvs (BAR) domain, and 2 C-terminal SH3 domains.