Dynein, Axonemal, Intermediate Chain 2 (DNAI2)

DNAI2 belongs to the dynein intermediate chain family, and is part of the dynein complex of respiratory cilia and sperm flagella. Mutations in this gene are associated with primary ciliary dyskinesia type 9. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

The DNAI2 gene encodes a deduced 605-amino acid protein containing 5 WD-40 repeats and several putative phosphorylation sites. Northern blot analysis revealed high expression of an approximately 2.4-kb DNAI2 transcript in trachea and testis.DNAH5 is essential for correct assembly of DNAI2 in outer dynein complexes.