Dynein, Cytoplasmic 1, Intermediate Chain 1 (DYNC1I1)

Cytoplasmic dynein is large multisubunit microtubule-based motor protein composed of heavy, intermediate, light-intermediate, and light chains. DNCI1, a gene encoding a cytoplasmic dynein intermediate chain. The DNCI1 gene contains 17 exons and spans approximately 160 kb. These authors also cloned cDNAs encoding mouse Dnci2 and several alternatively spliced isoforms of human and mouse Dnci1. The longest human isoform, DNCI1A, is a predicted 645-amino acid protein that is 97% and 98% identical to mouse and rat Dnci1, respectively. Northern blot analysis and in situ hybridization detected Dnci1 expression primarily in the developing mouse forebrain as well as in the peripheral nervous system. mouse Dnci1 had been mapped to mouse chromosome 6.