Dynein, Light Chain, Roadblock Type 1 (DYNLRB1)

The proteins share 77% sequence identity and show high homology to robl/LC7 dynein proteins. Northern blot analysis detected high expression of DNLC2A in heart, liver, brain, and pancreas, moderate expression in placenta, skeletal muscle, and kidney, and low expression in lung, prostate, testis, small intestine, and colon. Expression of DNLC2A was lower than that of DNLC2B in all normal tissues tested except liver. Northern blot and RT-PCR analysis in hepatocellular carcinoma (HCC) tissues of 68 Chinese patients showed upregulation of DNLC2A in 45 cases and dowregulation of DNLC2B in 44 cases compared with adjacent tumor-free liver tissues. In 7 additional cancer cell lines studied, DNLC2A was highly expressed in all, whereas DNLC2B was highly expressed in only 1 HCC cell line.