Dynein, Light Chain, Tctex Type 3 (DYNLT3)

DYNLT3 is a member of the dynein motor protein family. DYNLT3 binds to BUB3, a spindle checkpoint protein is present on kinetochores at prometaphase. DYNLT3 can also function as a transcription regulator of Bcl-2 gene through binding to SATB1 in a dynein-independent manner.The TCTE1L cDNA encodes a deduced 116-amino acid protein that shares 50.4% sequence identity with the mouse homolog, a member of the mouse t complex, which maps to chromosome 17. Genes in the mouse t complex are involved in sperm or male germ cell differentiation and are associated with male sterility and transmission ratio distortion. Northern blot analysis detected expression of a TCTE1L 2.1-kb mRNA in fetal and adult retina, as well as in fetal brain and adult frontal cortex, lung, heart, esophagus, testis, bone marrow, and fibroblasts..