Dystrobrevin Binding Protein 1 (DTNBP1)

DBND; HPS7; My031; SDY; Dysbindin; Biogenesis of lysosome-related organelles complex 1 subunit 8; Hermansky-Pudlak syndrome 7 protein
Dystrobrevin Binding Protein 1 (DTNBP1)
Dysbindin is a protein constituent of the dystrophin-associated protein complex (DPC) of skeletal muscle cells. It is also a part of BLOC-1, or biogenesis of lysosome-related organelles complex 1. Dysbindin was discovered by the research group of Derek Blake via yeast two-hybrid screening for binding partners of α-dystrobrevin. In addition, dysbindin is found in neural tissue of the brain, particularly in axon bundles and especially in certain axon terminals, notably mossy fiber synaptic terminals in the cerebellum and hippocampus.Probable dysbindin-related mechanisms causing brain dysfunction are not fully known, but in one study, schizophrenic patients carrying the high-risk haplotype demonstrated visual processing deficits. In another work, damping down the DTNBP1 expression led to an increase in cell surface dopamine D2-receptor levels.
Organism species: Homo sapiens (Human)
  • Protein RPC444Hu01Recombinant Dystrobrevin Binding Protein 1 (DTNBP1)Customize
  • AntibodyPAC444Hu01Polyclonal Antibody to Dystrobrevin Binding Protein 1 (DTNBP1)Customize
  • AntibodyMAC444Hu21Monoclonal Antibody to Dystrobrevin Binding Protein 1 (DTNBP1)Customize
  • Assay KitSEC444HuELISA Kit for Dystrobrevin Binding Protein 1 (DTNBP1)Customize
  • Assay KitSCC444HuCLIA Kit for Dystrobrevin Binding Protein 1 (DTNBP1)Customize
Organism species: Mus musculus (Mouse)
  • Protein RPC444Mu01Recombinant Dystrobrevin Binding Protein 1 (DTNBP1)Customize
  • AntibodyPAC444Mu01Polyclonal Antibody to Dystrobrevin Binding Protein 1 (DTNBP1)Customize
  • AntibodyMAC444Mu21Monoclonal Antibody to Dystrobrevin Binding Protein 1 (DTNBP1)Customize
  • Assay KitSEC444MuELISA Kit for Dystrobrevin Binding Protein 1 (DTNBP1)Customize
  • Assay KitSCC444MuCLIA Kit for Dystrobrevin Binding Protein 1 (DTNBP1)Customize
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