E74 Like Factor 1 (ELF1)

ELF1 contains a sequence motif that is highly related to the RB (retinoblastoma) binding sites of several viral oncoproteins and binds to the pocket region of RB1 both in vitro and in vivo. Other results demonstrated that RB interacts specifically with this lineage-restricted ETS transcription factor. The interaction may be important for the coordination of lineage-specific effector functions.

RAGS and ELF1, both ligands for EPH-related receptor tyrosine kinases, have been implicated in the control of development of the retinotectal projection. ELF1 has a repellent axon guidance function for temporal, but apparently not for nasal, axons. RAGS, on the other hand, is repellent for both types of axons, though to different degrees.