E74 Like Factor 5 (ELF5)

ELF5 is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.ESE2 expression was upregulated during keratinocyte differentiation, similar to that of ESE1, but occurred at a later stage. In electrophoretic mobility shift assays, ESE2a did not demonstrate specific binding to a Drosophila E74 ETS binding site.