Ecotropic Viral Integration Site 2A (EVI2A)

O'Connell et al. demonstrated by genetic linkage and by somatic cell hybrid and pulsed field gel electrophoresis that EVI2 (EVI2A), the human homolog of the mouse myeloid leukemia-associated gene Evi2, maps between 2 breakpoints on the proximal part of 17q that define the neurofibromatosis I region.

Cawthon et al. (1990) isolated EVI2A cDNAs from human bone marrow and frontal cortex cDNA libraries. The deduced 232-amino acid protein is predicted to be a glycosylated protein with a single membrane-spanning domain, a leucine zipper motif, and a cytoplasmic domain. There is a high degree of conservation between the human and mouse EVI2A proteins.