Ecotropic Viral Integration Site 5 Like Protein (EVI5L)

EVI5L is a member of the Ras superfamily of monomeric guanine nucleotide-binding (G) proteins, and functions as a GTPase-activating protein (GAP) with a broad specificity. Measurement of in vitro Rab-GAP activity has shown that EVI5L has significant Rab2A- and Rab10-GAP activity. The protein of EVI5L consists of 805[13] amino acid residues. The molecular weight of the mature protein is 92.5 kdal with an isoelectric point of 5.05. EVI5L has an unusually large amount of glutamic acid residues, compared to similar proteins. Most of the protein is neutral, with no positive charge, negative charge, or mixed charge clusters. It has a very small negative hydrophobicity (-0.597019). EVI5L is a soluble protein that localizes in the nucleus. It contains no signal peptide, no mitochondrial targeting motifs and no peroxisomal targeting signal in the C-terminus.