Ectodermal Neural Cortex Protein 2 (ENC2)

Ectoderm-neural cortex protein 2 is a protein by the KLHL25 gene. Kelch proteins (and Kelch-like proteins) are a widespread group of proteins that contain multiple Kelch motifs. The kelch domain generally occurs as a set of five to seven kelch repeats that form a β-propeller tertiary structure. Kelch-repeat β-propellers are generally involved in protein-protein interactions, though the large diversity of domain architectures and limited sequence identity between kelch motifs make characterisation of the kelch superfamily difficult.

The function of Kelch proteins is unknown. However they are commonly seen to associate with actin tails. The first Kelch protein was isolated from Drosophila. It has also been isolated in many other animals, bacteria, fungi, and even virus.