Emilin And Multimerin Domain Containing Protein 1 (EMU1)

EMID1 contains an N-terminal signal peptide, followed by an emilin (EMI) domain, 2 collagen stretches, and a novel C-terminal domain. The EMI domain contains 7 conserved cysteines that may mediate dimerization. In situ hybridization of day-9.5 mouse embryos detected Emid1 expression in the nephric duct, the dorsal neural tube, epithelia of branchial arches, and the otic vesicle. At later developmental stages, Emid1 was expressed in the dorsal spinal cord and brain, where it was restricted to the proliferating ependymal and cortical cell layers. It was also expressed in smooth muscles of the digestive tract. Emid1 and Emid2 were expressed at sites of epithelial mesenchymal interactions in several tissues, where Emid1 was restricted to the epithelium, and Emid2 to the surrounding mesenchyme.