Enabled Homolog (ENAH)

Enah, called Ndpp1The 3-prime UTR contains 7 ATTTA mRNA destabilization motifs. The deduced 389-amino acid protein has a proline-rich N terminus, followed by a leucine/proline-rich region, a 4-arginine cluster near a possible alpha helix, and a second possible alpha helix at the C terminus. Enah also has 3 putative N-glycosylation sites. Northern blot analysis detected a number of mRNA species that were downregulated during mouse embryonic development and were only faintly detected in adult mouse brain. Southern blot analysis of RT-PCR products found Enah expressed in several adult mouse tissues, with highest expression in heart and testis. Southern blot analysis detected homologs of mouse Enah in several vertebrate species, including human.