Erythroid Differentiation And Denucleation Factor 1 (EDDF1)
SLMO1; HFL-EDDG1; PRELID3A; C18orf43; Slowmo Homolog 1
Purified EDDF proteins bound specifically to the enhancer HS2 sequence of the globin gene activated the expression of haemoglobin in mouse erythroleukaemia and K562 erythroleukaemic cells and promoted them to differentiate into mature erythrocytes. EDDF proteins began to emerge at the pro-early erythroblast stages upon exposure to Epo in culture, and increased dramatically in early erythroblast stage. The dynamic of EDDF expression and its action on the key events of erythroblast differentiation and denucleation appeared to be closely consistent with its spatiotemporal distribution. These results suggest that EDDFs are the critical intracellular regulatory factors that may act as the successive regulators to Epo, responsible for the final stages of erythroid terminal differentiation.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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- Customized Service n/a Polyclonal Antibody to Erythroid Differentiation And Denucleation Factor 1 (EDDF1) Polyclonal Antibody Customized Service Offer
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Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Erythroid Differentiation And Denucleation Factor 1 (EDDF1) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Erythroid Differentiation And Denucleation Factor 1 (EDDF1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Erythroid Differentiation And Denucleation Factor 1 (EDDF1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Erythroid Differentiation And Denucleation Factor 1 (EDDF1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Erythroid Differentiation And Denucleation Factor 1 (EDDF1) ELISA Kit Customized Service Offer