Erythroid Differentiation Related Factor 1 (EDRF1)
C10orf137
EDRF1 influenced expression of alpha-globin mRNA and synthesis of hemoglobin in K562 cells and modulated self-renewal of K562 cells. To illuminate the function of EDRF1 in K562 cells, sense and antisense EDRF1 constructs were prepared and transfected into K562 cells. GATA-1 mRNA expression was modulated by EDRF1 gene transfection. Electrophoretic mobility shift assay suggested that the DNA-binding activity of GATA-1 was remarkably inhibited in K562 cells expressing EDRF1 antisense gene. DNA binding activity of NF-E2 was at the same level as control experiment. Therefore EDRF1 may play a role in erythroid proliferation and differentiation by affecting the interaction between GATA-1 and its cis-elements. EDRF1 regulated alpha- and gamma-globin gene synthesis by modulating DNA-binding activity of GATA-1 transcription factor.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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- Customized Service n/a Monoclonal Antibody to Erythroid Differentiation Related Factor 1 (EDRF1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Erythroid Differentiation Related Factor 1 (EDRF1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Erythroid Differentiation Related Factor 1 (EDRF1) CLIA Kit Customized Service Offer
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Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Erythroid Differentiation Related Factor 1 (EDRF1) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Erythroid Differentiation Related Factor 1 (EDRF1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Erythroid Differentiation Related Factor 1 (EDRF1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Erythroid Differentiation Related Factor 1 (EDRF1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Erythroid Differentiation Related Factor 1 (EDRF1) ELISA Kit Customized Service Offer