Ets Translocation Variant 2 (ETV2)

ETV2 contains 335 amino acids and may represent a partial sequence. Northern blot analysis of several mouse tissues detected a 1.7-kb transcript in adult testis and a 1.2-kb transcript in whole day-8.5 mouse embryos. No expression was detected in any other tissue examined.

Mouse Etv2 has 2 alternate translation start sites, resulting in proteins of 336 or 358 amino acids. Northern blot analysis detected a major 1.7-kb transcript and a minor 1.5-kb transcript in mouse testis. the mouse Etv2 gene contains 7 exons and spans 3 kb. The promoter region has no TATA box, but it has a functional Sp1-binding site. The human ETV2 gene also contains 7 exons.The deduced protein contains 370 amino acids.