Excision Repair Cross Complementing Rodent Repair Deficiency Complementation 1 (ERCC1)

UV20; DNA excision repair protein ERCC-1

Excision Repair Cross Complementing Rodent Repair Deficiency Complementation 1 (ERCC1)
ERCC1 functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease, and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)

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Organism species: Rattus norvegicus (Rat)

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  • Customized Service n/a Polyclonal Antibody to Excision Repair Cross Complementing Rodent Repair Deficiency Complementation 1 (ERCC1) Polyclonal Antibody Customized Service Offer
  • Customized Service n/a CLIA Kit for Excision Repair Cross Complementing Rodent Repair Deficiency Complementation 1 (ERCC1) CLIA Kit Customized Service Offer
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