Exocyst Complex Component 6B (EXOC6B)

In yeast and rat, Sec15 is part of a multiprotein complex that is required for targeted exocytosis. The deduced protein contains 710 amino acids, and the 3-prime untranslated region of the mRNA contains 4 MIR sequences. SEC15B shares 69.2% amino acid identity over 668 amino acids with rat Sec15.

RT-PCR ELISA detected low to moderate expression in most tissues and specific adult brain regions tested. Highest expression was detected in testis, ovary, and amygdala. Little or no expression was detected in skeletal muscle, pancreas, spleen, fetal liver, and fetal brain. Bat brain synaptosome Sec15b associated with RalA in a GTP-dependent manner as part of an exocyst complex.