Exophilin 5 (EXPH5)

EXPH5 contains 1,983 amino acids. RT-PCR detected highest EXPH5 expression in kidney, followed by lung, brain, liver, and ovary. Little to no expression was detected in skeletal muscle or spleen. Kuroda et al. (2002) showed that EXPH5, which they called SLAC2B, contains an N-terminal synaptotagmin-like homology domain (SHD).

Using a protein pulldown assay, Kuroda et al. (2002) found that the isolated N-terminal SHD of human SLAC2B and mouse Slp2a (SYTL2) bound RAB27A, but no other small GTP-binding protein examined. Coimmunoprecipitation analysis confirmed that full-length SLAC2B and SLP2A interacted specifically with RAB27A following transfection of COS-7 cells.