Exportin 7 (XPO7)

The small GTPase RAN plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.

A major, approximately 4.8-kb RANBP16 transcript was strongly expressed in testis, thyroid, and bone marrow, moderately expressed in many other tissues, and weakly expressed in lung, liver, and small intestine, but not expressed in thymus. Two other transcripts of approximately 3.5 and 2.5 kb were strongly expressed in bone marrow and the 3.5-kb transcript was also strongly expressed in testis. The mouse Ranbp16 gene was also ubiquitously expressed. Both RANBP16 and RANBP17 were found to be predominantly nuclear proteins.