Exudative Vitreoretinopathy 2 (EVR2)

The NDP gene encodes norrin, a secreted cysteine-rich protein that belongs to the cystine knot growth factor family .only exons 2 and 3 of the NDP gene are translated. Exon 2 contains the first 58 codons of the open reading frame. The intron that follows it is roughly 14.5 kb. Exon 3 is the largest exon and contains residues 59-133 of the open reading frame and a 917-bp 3-prime untranslated region.NDP protein has a tertiary structure similar to that of transforming growth factor-beta. The model identified NDP as a member of an emerging family of growth factors containing a cystine knot motif, with direct implications for the physiologic role of NDP.NDP gene spans 28 kb and contains 3 exons, the first of which is entirely contained within the 5-prime untranslated region.