F-Box And Leucine Rich Repeat Protein 20 (FBXL20)

Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin), and F-box proteins, act as protein-ubiquitin ligases.

The deduced 438-amino acid mouse protein contains an F box, leucine-rich repeats, and a C-terminal CAAX domain for prenylation and membrane targeting. Western blot analysis of mouse tissues showed highest protein levels in brain, and expression increased with development from midgestation to adult. In situ hybridization of mouse brain detected Scrapper enriched in CA1, CA3, and dentate gyrus regions of hippocampus, as well as in cerebellum and olfactory bulb. Immunofluorescence analysis detected colocalization of Scrapper with a presynapse marker in neurons.