F-Box Protein 36 (FBXO36)

Members of the F-box protein family, such as FBXO36, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).Jin et al. (2004) reported that the FBXO36 protein contains an F box in its C-terminal half.Jin et al. (2004) stated that the FBXO36 gene maps to chromosome 2q37.1 and the mouse Fbxo36 gene maps to chromosome 1C5.

F-box proteins are proteins containing at least one F-box domain. The first identified F-box protein is one of three components of the SCF complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome.