F Protein Binding Protein 1 (FBP1)

RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes.RAB14 staining partially overlapped with markers for early and recycling endosomes, cis-Golgi, and trans-Golgi network. Immunogold labeling of normal rat kidney cells revealed membrane-bound Rab14 associated with multiple membrane and vesicular structures. Most Rab14 was associated with small tubulo-vesicular structures throughout the cytoplasm, with Golgi stack and associated vesicles, and with endoplasmic reticulum. A minor fraction was associated with endosomal vacuoles and the plasma membrane.